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stem cell articles:

Milk miRNAs encapsulated in exosomes are stable to human digestion and permeable to intestinal barri

Milk exosomes encapsulating miRNAs are stable against human digestive processes. Uptake of milk exosomes in human intestinal cells is time dependent and saturable. Milk exosomal miRNAs can cross the barrier of human intestinal epithelium.

SIS-ECM Laden with GMSC-Derived Exosomes Promote Taste Bud Regeneration

Oral cancer has a high annual incidence rate all over the world, and the tongue is the most frequently affected anatomic structure. Our our findings indicate that GMSC/SIS-ECM and exosome/SIS-ECM constructs can facilitate taste bud regeneration and reinnervation with promising potential application in post surgery tongue reconstruction of patients with tongue cancer.

Exosomes: novel regulators of bone remodelling and potential therapeutic agents for orthodontics

Recent studies suggest that exosomes are involved in intercellular communication required for the maintenance of healthy bone. Exosomes collected from bone cells grown in culture may prove useful to augment bone remodeling associated with orthodontic force application or required for the repair of craniofacial bone.

The therapeutic potential of stem cells may largely be mediated by paracrine factors contained in ex

The therapeutic potential of stem cells may largely be mediated by paracrine factors contained in exosomes released from intracellular endosomes. A systematic review was performed to identify the effects of stem cell-derived exosomes for their ability to induce restorative effects in animal models of stroke.

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Wound healing is a highly orchestrated physiological process consisting of a complex events, and scarless wound healing is highly desired for the development and application in clinical medicine. Recently, we have demonstrated that human amniotic epithelial cells (hAECs) promoted wound healing and inhibited scar formation through a paracrine mechanism. However, exosomes (Exo) are one of the most important paracrine factors.

Dr. X Talks Stem Cell Research

Watch Doc X’s latest interview with Invitrx on groundbreaking Stem Cell Therapy research. #dentistry #oralhealth #teeth #dentalcare #dental #dentalhealth #oralcare #dentalclinic

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Severe psoriasis, a chronic inflammatory skin disease is increasingly being effectively managed by targeted immunotherapy but long-term immunotherapy poses health risk and loss of response. Therefore, there is a need for alternative therapy strategies. Mesenchymal stem/stromal cell (MSC) exosomes are widely known for their potent immunomodulatory properties. Here we investigated if topically applied MSC exosomes could alleviate psoriasis-associated inflammation.

Emerging role of Exosomes in Craniofacial and Dental Applications

Exosomes, a specific subgroup of extracellular vesicles that are secreted by cells, have been recognized as important mediators of intercellular communication. They participate in a diverse range of physiological and pathological processes. Given the capability of exosomes to carry molecular cargos and transfer bioactive components, exosome-based disease diagnosis and therapeutics have been extensively studied over the past few decades. Herein, we highlight the emerging applications of exosomes.

Exosomes Isolated From Platelet-Rich Plasma and Mesenchymal Stem Cells Promote Recovery of Function

Clinical use of platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) has gained momentum as treatment for muscle injuries. Exosomes could be helpful if they could deliver the same or better physiological effect without cell transplantation into the muscle.

Topical Application of Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells in Combinat

The topical application of exosomes secreted by mesenchymal stem cells (MSC-Exos) on the skin is a very new and interesting topic in the medical field. In this study, we aimed to investigate whether marine sponge Haliclona sp. spicules (SHSs) could effectively enhance the skin delivery of human umbilical cord-derived MSC-Exos (hucMSC-Exos), and further evaluate the topical application of hucMSC-Exos combined with SHSs in rejuvenating photoaged mouse skin.

BAYLX,INC. Announced Clearance of COVID-19 IND From US FDA For Cord Mesenchymal Stem Cells

Baylx, Inc. (Baylx), a clinical-stage stem cell biopharmaceutical company focused on developing living stem cell products to address unmet medical needs, today announced that the U.S. Food and Drug Administration (FDA) cleared Baylx's Investigational New Drug (IND) application for BX-U001, a fresh, non-frozen human umbilical cord tissue mesenchymal stem cells (hUC-MSC) productin patients with COVID-19.

Exosomes influence the behavior of human mesenchymal stem cells on titanium surfaces

Mesenchymal cells and macrophages are among the cells that are detected in the implant Titanium (Ti) implant-tissue interface during the very early stages of osseointegration. These cells interact with each other and with the implant surface. These cell-to-cell and cell-material interactions are linked to regenerative processes and involve the transfer of exosomes between cells since monocyte-derived exosomes are internalized by recipient MSCs and promote MSC osteogenic differentiation.

Caffeine Augments The Instruction of Anti-Inflammatory Macrophages by The Conditioned Medium of Mese

Mesenchymal stem cells (MSCs) have been shown to produce adenosine, express adenosine receptors, and communicate with macrophages and other cells. However, there is no information about the role of caffeine, as a popular drink and adenosine antagonist, on the crosstalk between MSCs and immune cells. The aim of the current study is to evaluate the effects of the conditioned medium of MSCs treated with caffeine on macrophages.

Emerging functions and clinical applications of exosomes in Human Oral Diseases

Exosomes are cell-derived membranous vesicles of endosomal origin secreted by all type of cells and present in various body fuids. Exosomes are enriched in peptides, lipids, and nucleic acids, emerging as vital modulators in intercellular communication. Exosomes are increasingly being evaluated as biomarkers for diagnosis and prognosis of diseases, because the constituents of exosomes could be reprogrammed depending on the states of diseases. These features also make exosomes a research hotspot.

FDA clears IND application for cell therapy to treat radiotherapy-induced dry mouth

The FDA cleared an investigational new drug application for a mesenchymal stromal cell therapy to treat radiotherapy-induced xerostomia, also known as dry mouth.